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  • Clamp loader ATPases and the evolution of DNA replication

    Apr 20, 2012 · The U.S. Department of Energy's Office of Scientific and Technical Information

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  • Structure of the human clamp loader reveals an

    the replication factor C (RFC) sliding clamp loader. Clamp loaders are pentameric ATPase machines that can open the sliding clamp and close it around DNA. Clamp loaders are found in all life, although their composition varies across different kingdoms (10). The primary clamp loader in eukaryotes con-sists of five distinct proteins, RFC1–5.

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  • Interactional similarities and differences in the protein

    Jun 14, 2019 · Johnson A, Yao NY, Bowman GD, Kuriyan J, O'Donnell M. The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 2006;281:35531–43. CAS Article Google Scholar 13. …

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  • Replication factor C (RFC).

    Nov 19, 2014 · The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 2006; 281 :35531–35543. doi: 10.1074/jbc.M606090200.

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  • TheReplicationFactorCClampLoaderRequiresArginine

    Johnson,A., Yao,N.Y., Bowman,G.D., Kuriyan,J. and O'Donnell,M. (2006) The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem 281, 35531-35543. 6.

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  • Interactional similarities and differences in the protein

    Jun 14, 2019 · Johnson A, Yao NY, Bowman GD, Kuriyan J, O'Donnell M. The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 2006;281:35531–43. CAS Article Google Scholar 13. …

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  • The replication factor C clamp loader requires arginine

    Apr 20, 2012 · The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 2006; 281 :35531–35543. doi: 10.1074/jbc.M606090200.

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  • PCNA Loading by RFC, Mechanism of | SpringerLink

    Jan 30, 2018 · Johnson A, Yao NY, Bowman GD, Kuriyan J, O'Donnell M (2006) The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem 281(46):35531–35543 PubMed CrossRef Google Scholar

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  • The ATP Sites of AAA+ Clamp Loaders Work Together as a

    The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J. Biol. Chem. 2006; 281 : 35531-35543 Abstract

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  • ( A ) RFC small-subunit apo-protein hexamer viewed from

    A crystal structure shows the yeast clamp loader RFC (replication factor C), a pentameric AAA+ adenosine triphosphatase (ATPase) (2)(3)(4) (5) (6)(7)(8), in complex with its corresponding clamp in

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  • Clamp loader ATPases and the evolution of DNA …

    The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 2006; 281 :35531–35543. [ PubMed ]

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  • Levels of human replication factor C4, a clamp loader

    Nov 19, 2014 · Johnson A, Yao NY, Bowman GD, Kuriyan J, O'Donnell M: The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 2006, 281: 35531-35543. 10.1074/jbc.M606090200. Article CAS …

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  • The replication factor C clamp loader requires arginine

    The Replication Factor C Clamp Loader Requires Arginine Finger Sensors to Drive DNA Binding and Proliferating Cell Nuclear Antigen Loading*♦ Previous Article The Ins and Outs of MYC Regulation by Posttranslational Mechanisms*

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  • Aaron Johnson - Publications

    The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. The Journal of Biological Chemistry. 281: 35531-43. PMID 16980295 DOI: 10.1074/jbc.M606090200 : 0.36: 2006: Yao NY, Johnson A, Bowman GD, Kuriyan J, O'Donnell M. Mechanism of proliferating cell nuclear

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  • shRNA-mediated silencing of the RFC3 gene suppresses

    Sep 21, 2015 · Johnson A, Yao NY, Bowman GD, Kuriyan J and O'Donnell M: The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem. 281:35531–35543. 2006. View Article: Google Scholar: PubMed/NCBI. 25

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  • Levels of human replication factor C4, a clamp loader

    Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorectal cancer (CRC). The mRNA levels of RFC4 were assessed in 30 paired primary CRC tissues and matched normal colonic tissues by quantitative PCR. The protein expression levels of RFC4 were

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  • THE J BIOLOGICAL C © 2003 by The American Society for

    Replication factor C (RFC) is a heteropentameric AAA protein clamp loader of the proliferating cell nuclear an-tigen (PCNA) processivity factor. The prokaryotic homo-logue, complex, is also a heteropentamer, and structural studies show the subunits are arranged in a circle. In this report, Saccharomyces cerevisiae RFC protomers are ex-

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  • Improved solubility of replication factor C (RFC) Walker A

    Jun 01, 2012 · It has been shown previously that the S. cerevisiae clamp loader replication factor C (RFC), and particularly complexes harboring Walker A mutations, have decreased stability, in part due to protein aggregation, .Though Gomes et al. showed that the addition of 0.05% broad range ampholytes (pH 3.5–9) increased RFC solubility, this additive was not effective at concentrations and under

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  • The Structure of a Ring-Opened Proliferating Cell Nuclear

    a clamp-loader [replication factor C (RFC)] complex and the energy derived from ATP hydrolysis. The mechanistic and structural details regarding PCNA loading by the RFC complex are still developing. In particular, the positive identification of a long-hypothesized struc-ture of an open clamp-RFC complex as an intermediate in loading has

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  • RCSB PDB - 2CHV: Replication Factor C ADPNP complex

    Mar 16, 2006 · We have investigated the communication between subunits in replication factor C (RFC) from Archaeoglobus fulgidus. Mutation of the proposed arginine finger in the small subunits results in a complex that can still bind ATP but has impaired clamp-loading activity, a process that normally only requires binding of nucleotide.

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