Roewe Loader Charger

  • Downtown Tunnels | Downtown Houston

    DOWNTOWN'S "underground" is a system of tunnels 20 feet below Houston's downtown streets and more than 6 miles long.Having started out years ago as a tunnel between two downtown movie theaters, today it includes restaurants and service retail and connects 95 city blocks.

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  • REVIEW Open Access Clamp loader ATPases and the …

    Clamp loaders are pentameric ATPases of the AAA+ family that operate to ensure processive DNA the clamp loader is critical for the tight coupling of leading and lagging strand synthesis. Indeed, in bacteria the clamp loader acts physically to ˚e clamp loader shares an essential aspect of its

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  • Downtown Tunnels | Downtown Houston

    DOWNTOWN'S "underground" is a system of tunnels 20 feet below Houston's downtown streets and more than 6 miles long.Having started out years ago as a tunnel between two downtown movie theaters, today it includes restaurants and service retail and connects 95 city blocks.

    Learn More
  • Identification of Putative Mitochondrial Protease

    Nov 24, 2020 · Graef M, Seewald G, Langer T (2007) Substrate recognition by AAA+ ATPases: distinct substrate binding modes in ATP-dependent protease Yme1 of the mitochondrial intermembrane space. Mol Cell Biol 27:2476–2485.

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  • The Protease ClpXP and the PAS Domain Protein DivL

    May 17, 2018 · Jenal U, Fuchs T. 1998. An essential protease involved in bacterial cell-cycle control. Shapiro L. 2006. A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression. Proc Natl Critical clamp loader processing by an essential AAA+ protease in Caulobacter

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  • Structure of the human clamp loader bound to the sliding

    Feb 18, 2020 · Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism Christl Gaubitza‡, Xingchen Liua,b‡, Joseph Magrinoa,b, Nicholas P. Stonea, Jacob Landecka,b, Mark Hedglinc, Brian A. Kelcha,¶ a Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester MA b Graduate School of Biomedical …

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  • Let us know how access to this document benefits you.

    and installed onto DNA by a clamp loader ATPase of the AAA+ family. The human clamp loader Replication Factor C (RFC) and sliding clamp PCNA are both essential and play critical roles in several diseases. Despite decades of study, no structure of human RFC has been resolved. Here, we report t he structure of human RFC

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  • Publications – Chien Lab

    18. Vass, RH, Chien P. "Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus." Simmons LA, Walker GC. "Sinorhizobium meliloti CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection." Perchuk BS, Laub MT, Sauer RT, Baker TA. "Direct and adaptor-mediated

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  • The Essential Role of ClpXP in Caulobacter crescentus

    The ClpXP protease is a highly conserved AAA+ degradation machine that is present throughout bacteria and in eukaryotic organelles. ClpXP is essential in some bacteria, such as Caulobacter crescentus, but dispensible in others, such as Escherichia coli.In Caulobacter, ClpXP normally degrades the SocB toxin and increased levels of SocB result in cell death.

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  • Critical clamp loader processing by an essential AAA+

    Nov 01, 2013 · Here, we show that in Caulobacter crescentus, DnaX isoforms are unexpectedly generated through partial proteolysis by the AAA+ protease casein lytic proteinase (Clp) XP. We find that the normally processive ClpXP protease partially degrades DnaX to produce stable fragments upon encountering a glycine-rich region adjacent to a structured domain.

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  • AAA+ proteins: have engine, will work | Nature Reviews

    Jul 01, 2005 · The cytoplasmic AAA+ protein p97/VCP is essential for removing numerous ERAD protein substrates from the membrane 57, and has recently been shown to …

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  • The Protease ClpXP and the PAS Domain Protein DivL

    May 17, 2018 · Jenal U, Fuchs T. 1998. An essential protease involved in bacterial cell-cycle control. Shapiro L. 2006. A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression. Proc Natl Critical clamp loader processing by an essential AAA+ protease in Caulobacter

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  • The AAA+ superfamily of functionally diverse proteins

    Apr 30, 2008 · The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module.

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  • Protease regulation and capacity during Caulobacter growth

    Dec 01, 2016 · Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus Proc Natl Acad Sci U S A, 110 ( 2013 ), pp. 18138 - 18143 CrossRef View Record in …

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  • Critical clamp loader processing by an essential AAA+

    Nov 05, 2013 · Chromosome replication requires sliding clamps that are loaded by clamp loader complexes. In Escherichia coli, these complexes exist as long (tau) and short …

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  • AAA+ proteins: Current Biology - cell.com

    Mar 23, 2020 · The first and minimal AAA+ clade, the clamp loader, is conserved in bacterial, archaeal and eukaryotic species and its functions include DNA replication and repair. Proteins belonging to this clade do not have any additional structural elements inserted in their AAA+ domain (Figure 1B). Instead, they have specialized regions outside of the AAA+

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  • Protease regulation and capacity during Caulobacter growth

    Dec 01, 2016 · Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus Proc Natl Acad Sci U S A, 110 ( 2013 ), pp. 18138 - 18143 CrossRef View Record in …

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  • Critical clamp loader processing by an essential AAA+

    Oct 21, 2013 · Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Robert H Vass Molecular and Cellular Biology Graduate Program, Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003.

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  • Slipping up: Partial substrate degradation by ATP

    May 14, 2014 · Degradation by ClpXP was also stalled by the insertion of a GRR in front of barnase 56, and the processing of the clamp loader DnaX in C. crescentus similarly involves a GRR adjacent to a folded domain 31, indicating that slippery substrates are physiologically relevant in prokaryotes as well as eukaryotes, suggesting a conserved processing

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  • The Mouse Heart Mitochondria N Terminome Provides Insights

    Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress. Global analysis of the mitochondrial N-proteome identifies a processing peptidase

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